![]() īecause adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Pediatric patients may be more susceptible to systemic toxicity due to their larger skin-surface-to-body mass ratios. If HPA axis suppression is documented, gradually withdraw the drug, reduce the frequency of application, or substitute with a less potent corticosteroid. ![]() In addition, 2 separate trials in pediatric subjects demonstrated adrenal suppression as determined by cosyntropin testing. The effect on morning plasma cortisol was transient and subjects recovered 1 week after discontinuing dosing. One of these subjects had an abnormal cosyntropin test. Three of the 8 normal subjects on whom clotrimazole and betamethasone dipropionate cream was applied exhibited low morning plasma cortisol levels during treatment. In a small trial, clotrimazole and betamethasone dipropionate cream was applied using large dosages, 7 g daily for 14 days (BID) to the crural area of normal adult subjects. This may be done by using the adrenocorticotropic hormone (ACTH) stimulation test. ![]() Factors that predispose a patient to HPA axis suppression include the use of high-potency steroids, large treatment surface areas, prolonged use, use of occlusive dressing, altered skin barrier, liver failure, and young age.īecause of the potential for systemic corticosteroid effects, patients may need to be periodically evaluated for HPA axis suppression. Cushing's syndrome and hyperglycemia may also occur due to the systemic effect of corticosteroids while on treatment. This may occur during treatment or after withdrawal of treatment. Wash hands after each application.Ĭlotrimazole and betamethasone dipropionate cream can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency. It is not for oral, ophthalmic, or intravaginal use.Īvoid contact with eyes. If a patient shows no clinical improvement after 2 weeks of treatment with clotrimazole and betamethasone dipropionate cream, the diagnosis should be reviewed.Ĭlotrimazole and betamethasone dipropionate cream is for topical use only.Gently massage a sufficient amount of clotrimazole and betamethasone dipropionate cream into the affected skin areas twice a day for two weeks.If a patient shows no clinical improvement after 1 week of treatment with clotrimazole and betamethasone dipropionate cream, the diagnosis should be reviewed.Do not use more than 45 grams per week.Apply a thin film of clotrimazole and betamethasone dipropionate cream into the affected skin areas twice a day for one week.Treatment of tinea corporis or tinea cruris: Clotrimazole Betamethasone Cream Dosage and Administration
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